Subjects Medical Nonfiction. Medical Nonfiction. Format OverDrive Read 4. More about Jarkko Rautio.
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Upon prodrug administration, an enzyme coded by a viral vector in the tumor cell leads to produce cytotoxic metabolite which results in direct tumor cell death Fig. Pharmaceuticals Basel. Open Access publishing is therefore of utmost importance for wider dissemination of information, and will help serving the best interest of the scientific community. Molecules ; 14 11 : Fragment-based Drug Discovery.
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Jarkko Rautio. First published: 15 December About this book This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development. Other books in this series.
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This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated. Prodrugs and Targeted Delivery: Towards Better ADME Properties, Volume Editor(s). Prof. Dr. Jarkko Rautio. First published December.
Phosphodiesterases and Their Inhibitors Raimund Mannhold. Back cover copy By definition, drugs are highly active substances that are beneficial if they act at the right time and in the right place, but can cause harm otherwise. A clever strategy to ensure that a drug only becomes active when needed is to "camouflage" it.